Oregano ( Origanum vulgare): The essential oil of oregano has broad-spectrum antimicrobial properties, inhibiting candida growth and diminishing its virulence.,, , Colostrum can be a particularly effective treatment for GI pathogens and dysbiosis in settings of immunodeficiency. Colostrum also provides growth factors that support mucosal healing and repair, while lactoferrin exerts broad antimicrobial effects, with numerous studies showing its effectivity against candida in vitro and in vivo. 11Ĭolostrum and lactoferrin: Colostrum provides immunoglobulins, proline-rich peptides, and a small amount of lactoferrin, each factors that support a normal immune response and help protect against infection. boulardii, also improving tissue healing and resolution of inflammation. rhamnosus GG have been shown to reduce the formation of candida-related biofilms and candida colonisation via mechanisms similar to S. boulardii inhibits candida filamentation, adhesion, and biofilm formation, and also supports mucosal production of secretory IgA, a factor that helps protect against candida and other infections. Saccharomyces boulardii: A probiotic yeast, boulardii has been shown to decrease candida colonisation and related inflammation. Below is a list of considerations for candida overgrowth and data supporting its use as a therapy: If we only use hard-hitting antifungals to eradicate candida, it will likely return in full force because we haven’t addressed the terrain that leads to colonisation to begin with. Taming Candida Overgrowthīecause the presence of candida is normal, we must consider the factors that lead to its overgrowth when addressing treatment. Such tests give us a starting point for addressing candida colonisation-though, much like SIBO, many factors are necessary to consider for its successful resolution. Given this knowledge, is it really appropriate for us to neglect considering GI candida colonisation (and its treatment) completely, particularly in the presence of these often-chronic conditions? Much like the LBT for SIBO, testing is plagued by the lack of an absolute threshold at which treatment is indicated however, there are tests that indicate the magnitude of overgrowth and candida viability (as indicated by culture), as well as sensitivity to different antifungal agents (both natural and pharmaceutical). , In the gut, candida colonisation also is associated with constipation, Increased faecal candida counts have been shown in patients with inflammatory bowel disease, 8 and, in individuals with ulcerative colitis, the lack of treating these patients with an antifungal has been shown to be associated with an increased level of disease activity. is normal in the gastrointestinal (GI) tract, and does not warrant treatment, even though multiple studies have shown higher faecal levels of candida in conditions such as antibiotic-associated diarrhea. Although we medically recognize an overgrowth of candida on the skin, vulvovaginal tissues, oral cavity, and numerous other locations as an indication for treatment, medical guidelines state that the presence of Candida spp. Many of the factors that contribute to SIBO are also well-documented to contribute to candida colonization. In this population, it is imperative that we consider other factors that may coexist leading to the symptomology that we often ascribe to SIBO. However, in some patients, SIBO is seemingly resistant to treatment, even after many cycles of otherwise effective therapies. , įortunately, for many diagnosed with SIBO, symptoms do improve with a combination of dietary modification, digestive support (supplemental hydrochloric acid, enzymes, and/or ox bile), and antibiotics and/or herbal antimicrobials-and, in those with constipation, support for normal motility. SIBO has a lot of hype-and how can it not, with so many conferences, practitioners, and clinics focused on its treatment? Given that the lactulose breath test (LBT), commonly used for the diagnosis of SIBO, has a low sensitivity and frequently gives false-positive results (although sensitivity can be improved via three-hour methane and hydrogen testing), it can be overused for the ease of diagnosing, well, something. Nowadays, with any mention of digestive symptoms of constipation, diarrhoea, gas, or bloating, and a history of antibiotic or proton-pump inhibitor use, one of the first things most integrative healthcare practitioners will consider in the differential diagnosis list is gastrointestinal dysbiosis with testing for small intestinal bacterial overgrowth (SIBO).
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